Glow

Glow GHK 70mg+BPC 10mg+TB500 10mg）

GHK-Cu,BPC-157 andTB500 are, separately, some of the most potent anti-inflammatory peptides that have been investigated. Each of these peptides has been found to promote wound healing, slow tissue decay, promote muscle and tendon growth, alter DNA expression patterns, and even thwart the effects of aging. Despite their similar properties, however, each of these peptides works in a different way to bring about its various effects. Thus, logic would dictate that using these peptides in conjunction with one another could result in synergies in each of the areas mentioned above.

To aid in research into the combined effects of these peptides, a Glow (GHK 70mg+BPC 10mg+TB500 10mg） Blend has been created. This blend makes ordering, storage, dosing, and administration of these peptides easier, allowing researchers to focus on measuring outcomes and designing experiments rather than creating protocols for administering multiple individual peptides.

What follows is a look at how BPC-157, TB500, and GHK-Cu might work in conjunction and why they might produce synergistic (i.e. enhanced effects) when used in combination. This overview will likely provide some guidance on what animal studies using these peptides in combination might uncover and where scientists should expect to see results.

GHK-Cu: Biochemistry

GHK-Cu is a naturally occurring coper complex consisting of a short peptide bound to copper II. It was first isolated in human plasma, but has been found in saliva and urine as well. It has been shown in animal studies to be important in wound healing and inflammatory responses. It is well-known for its ability to stimulate collagen synthesis as well as skin fibroblast growth. As a result of these latter properties, GHK-Cu is found in many cosmetic products where it is touted as an anti-aging ingredient.

GHK-Cu is thought to work by stimulating the synthesis of enzymes called metalloproteinases. These enzymes break apart certain proteins to promote wound healing. It also stimulates the production of anti-proteases, which prevent the breakdown of other proteins. Like BPC-157, GHK-Cu appears to coordinate a complex mechanism of protein deposition and breakdown via gene regulation. Thus, it helps to coordinate the overall process of wound healing, particularly dermal repair.

BPC-157: Biochemistry

BPC-157 is a penta-decapeptide derived from the naturally occurring Body Protective Compound (BPC). BPC was originally derived from human gastric contents and has been shown to have potent anti-inflammatory and wound-healing properties. Animal studies have indicated benefit in the GI tract, liver, pancreas, ligaments, muscles, tendons, cornea, heart, brain, and nerves.

The precise way in which BPC-157 produces its effects is still not clearly understood. For instance, it isn’t clear if the peptide binds to a cell surface receptor to produce its effects or if it is transported into the cell and perhaps has effects directly at the level of the DNA. A few things about BPC-157 have become clear from the research, however. First, BPC-157 has profound effects on nitric oxide (NO) signaling. Many of its properties are thought to relate, in some way, to the ability of BPC-157 to influence NO signaling at the levels of eNOS expression.

Second, BPC-157 is rapidly absorbed and distributed throughout the body. Research shows that 10 minutes after administration, BPC-157 can be found relatively evenly spread throughout the body including kidney, liver, stomach wall, thymus, gonads, and spleen. Peak levels of the peptide are achieved in tissue approximately 1 hour after administration and then slowly decline over the next 48 hours [1]. Levels tend to me highest in kidney, liver, thymus, and spleen with slightly lower levels in lung, muscle, brain, and skin. 

The third thing that can be concluded about the biochemistry of BPC-157 is that it alters gene expression patterns. Again, the mechanism by which this occurs has yet to be elucidated, but the peptide definitely alters expression patterns of: 

• Egr, 
• Nos (especially eNos), 
• Srf, 
• Vegr, 
• Plcγ, and 
• Kras. 

These genes control the synthesis of a number of factors that affect cells of blood vessels and the immune system such as adhesion, thrombosis, and inflammatory responses. The levels of each gene increased or decreased based on the timeframe following administration of BPC-157. This suggests that BPC-157 is working through a regulatory mechanism that has fine-grained control over a wide array of genes and their expression.

TB500: Biochemistry

TB500 is a derivative of thymosin beta-4, a naturally occurring protein with known anti-inflammatory and tissue healing properties. Like thymosin beta-4, TB500 primarily works to bind actin and regulate gene expression. It has shown benefits in heart health, muscle repair, immune regulation, and the central nervous system. It even has been shown to promote hair growth and to fight the effects of aging.

TB500 has two primary mechanisms of action. First, within the cell TB500 works to sequester actin and thus regulate everything from cell motility to growth and division. This role is critical to everything from wound healing to the movement of cells of the immune system to where they are needed. Boosting cell motility via TB500 administration has been shown to accelerate wound healing, reduce inflammation, and promote blood vessel growth.

The second role of TB500, which is sometimes referred to as moonlighting, is to regulate inflammation through changes in gene expression patterns rather than via actin sequestration. Research shows that TB500 alters the expression of genes involved in nitric oxide synthesis, blood vessel growth, cell proliferation, and more. These effects, in fact, are very similar to the downstream effects of BPC-157 discussed in the previous section. TB500 essentially alters the secretion patterns of various cytokines and plays a key role in modulating multiple signaling pathways related to the inflammatory response. It helps reduce inflammation by regulating the NF-κB and Toll-like receptor pathways and by suppressing the release of pro-inflammatory cytokines such as TNF-α and IL-1 receptor-associated kinases. TB500 also activates a number of tissue repair pathways including PI3K/Akt/eNOS, Notch, and angiopoietin-1/Tie2 to support regeneration. Additionally, it modulates the TGF-β pathway to reduce fibrosis (i.e. scarring). There is even evidence showing that TB500 influences Wnt signaling to promote the formation of hair follicles and boost hair growth at the level of DNA.